Just a reminder: Followups, sequels, prequels, etc are NOT reboots. If it was, I'd go on about my plans for followups to Hey Arnold, Doug, Queer as Folk, Batman Beyond (a primetime drama tied into the new comics), possibly Jem (and only then just a short-lived series that essentially serves as a proper ending to the series), Invader Zim, 100 Deeds for Eddie McDowd, VR Troopers (though I plan on doing that with my reboot concept) and so on.
As a more serious sci-fi drama, possibly on the CW.
It'd be basically the same formula, albeit retooled for a teen audience.
Expand the series to an hour-long timeslot featuring three stories, each told by a different host, which would be The Cryptkeeper and the other two hosts from the comics, The Vaultkeeper and The Old Witch.
It'd make more sense now than it did over 10 years ago. For one, it was during the '70s nostalgia boom. For another, it was associated and compared to That '70s Show.
But since '80s nostalgia is big now, it could very well potentially fare much better.
Just work on what made the original version less than perfect and how That '70s Show approached the time period it was set in.