well, it's a little more like, my brain is wired for me to live my whole life with my left hand as primary , not just game controllers...So the problem is that you got so used to playing with the d-pad on the left side, that if you swtich hands to favor the pointer wiimote like everyone is suggesting, the analogue stick feels weird on that side. Vice versa, the pointer feels weird on the right.
I use my mouse left handed too, baseball bats, guitars, knives axes, all hand tools.
it really makes no sense to me that these things arn't made symmetrical with button assignments in the software. I was wanting to buy the split fish mouse controller (or fragnstein) but they're for rightys so I'm screwed there too. if I could get any of these things cheap 2nd hand I'd consider modding them, cut and fit buttons to different locations, but ya know I'd probably end up with more time invested in the mod that I would ever spend playing the games....
oh well gotta love those product engineers.