Favorite Game Boss Fight

[Razzmatazz]

Resident Evil 4 - The chief in the burning barn.
Ninja Gaiden (xb) - The bone dragon. The big slime in the street. The Goku battle. In fact this game has some incredible battles. Might dig this out!
Ocarina of Time - Dark Link, very challenging but was so happy when he was put to rest.
Trauma Center New Blood - beating that prick on TV.
Goldeneye - Trevelyan
Gears of War 1 - Final boss. Doing that on Insane was intensity itself.

[Gamerforlife]

Another one of my favorites from Lollipop Chainsaw. It's the stage 3 boss. The concept is funny and cool. The music for the first and final stages of the fight are great (though hard to hear above the sounds of battle, check out this game's excellent OST on youtube). It's also well designed. I love that you can get a trophy/achievement for skillfully dodging all the bubble attacks encouraging skillful play. Plus, any time you have to use the gun provides a nice change of pace since most of the game plays like a beat'em up. I have some complaints with certain aspects of Lollipop Chainsaw's gameplay, but I was pretty happy overall with the boss fights. Suda outdid himself there

[Godot102]

Nemesis (Resident Evil 3), Goro (Mortal Kombat), Bowser (Super Mario 64) and Dr. Robotnik (Sonic 2) are the main names that come to mind. The replay value in all of those games are great and those boss battles seem to never get old to me.

Recently, one that I've been getting some enjoyment and that's mainly thanks to my best friend is the Master Hand (Super Smash Bros). Last summer I was getting her into SSB and we started with the N64 version. The moment Master Hand showed up her reaction was priceless.

I love the master hand theme in that game! I really wish it was also in brawl...

[WallCrusher]

In recent memory, fighting Goht in Majora's Mask is pretty damn awesome, fighting him the way the game intends by turning into a Goron, chasing after him, hitting a ramp, and then crashing yourself into him.

Another Zelda boss from recent memory that was like this was Koloktos from Skyward Sword. Stealing his own weapon and then hacking off his arms and legs, and then breaking open his chest to expose his weakpoint is so incredibly satisfying.