Just to add -- Saturn rips can be extremely picky about what program you use to burn them. If you know what dumping group did the dump (Trurip, TOSEC-ISO, Redump, Darkwater) I would google them to find out who they say to use to burn their discs. I had several games that were perfectly playable but with intermittently messed up audio, very similar to what you're describing, and the problem was I wasn't using the burning program that the dumping group recommended. Switch to the recommended one and it cleared it right up.
If you don't know what dumping ground did the dump... get a new dump.